To submit a manuscript to PMC via NIHMS, you will first need to log in to the NIHMS system (see What login route should I select on the NIHMS homepage?). Once you are logged in, click the Submit New Manuscript button and follow the guidance provided in the interactive "walkthrough" (you may access this feature in the Submission interface by clicking the icon on the right-hand side of the screen). Step-by-step tutorials on the NIHMS submission and approval processes are also available on the NIHMS Tutorials page.